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A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression

It targets not just one, but several core mechanisms of aging simultaneously: telomere maintenance, epigenetic regulation, oxidative stress resilience, immune recalibration, and circadian rhythm restoration [1]

You make this inquiry of your doctor, and in the traditional practice of clinicians he offers to start you on anti-depressant medications targeting serotonin/dopamine levels

Xanthine oxidase Xanthine oxidase (XO) is a flavin-containing isoenzyme of xanthine oxidoreductase (XOR) that catalyzes the oxidation of hypoxanthine to xanthine and, in the next step, xanthine to uric acid (Burrage et al