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R., Dermargos, A., Curi, R., & Hatanaka, E

Medications that can result in edema include vasodilators, calcium channel blockers used to treat hypertension, non-steroidal anti-inflammatory drugs, estrogen therapies, and some diabetes medications

holds research grants from the National Institute for Health Research, Research for Patient Benefit (NIHR RfPB), a Medical Research Council Wellcome Strategic grant (WT089698) and a grant from Parkinsons UK (G-1009) and has received honoraria and/or financial support to speak and/or attend meetings from Allergan, Boehringer-Ingelheim, GSK, Ipsen, Lundbeck, Merz, Orion, Sun Pharma and Teva

This suggests that while oral forms provide gastroprotective effects through local action, systemic therapeutic benefits require higher concentrations