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2009 Aug;136(2):381-6

10.1177/2048872617710789 59 HuangK.QueJ.HuZ.YuY.ZhouY.WangL.et al (2020)

In monocyte/macrophage lineages, pharmacological modulation via the metabolic agent metformin achieves dual therapeutic effects by impairing monocyte-to-macrophage differentiation, consequently attenuating age-related macrophage senescence and systemic immune dysfunction