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Additionally, antioxidant compounds in aniseed may contribute to its antidepressant activity by inhibiting the reuptake of serotonin and monoamine oxidase, thus increasing serotonin levels in the synaptic clefts and enhancing receptor sensitivity

Sorensen, S.B., Bech, L./ M., Muldbjerg, M., Beenfeldt, T

Combined with the high cost of treatment, it results in a substantial socioeconomic burden ( The discovery of tumor necrosis factor (TNF-) as a crucial cytokine in the pathogenesis of ARDs as rheumatoid arthritis (RA) led to the development of the first group of biologic drugs: TNF- inhibitor ( Great progress has been made in cell therapy particularly due to the development of genetically modified receptors, such as chimeric antigen receptors (CARs) in T cells (CAR-T)

The maintenance of glutamate homeostasis largely relies on the activity of astrocytic transporters that under physiological conditions clear glutamate from the synaptic cleft (Bylicky et al., 1994