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Stem Cell Rep (2016) 7:27991

For IPGTTs, mice were fasted for 6 h prior to administration of a 2 g/kg BW glucose bolus

In the context of protein translation initiation, S6K1 phosphorylates and activates eIF4B (eukaryotic translation initiation factor 4B), a positive regulator of the 5-cap-binding eIF4F (eukaryotic translation initiation factor 4F) complex, thus promoting translation of mRNAs with complex 5 untranslated regions (Holz et al., 2005)