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Figure 11 3.14 The impact of C75 on the lipid metabolism in vivo Finally, immunohistochemical analysis showed that, except for Acsl1 ( Figures 11K, Q ), the expression of lipid metabolism-related genes Fasn ( Figures 11G, M ), Scd1 ( Figures 11H, N ), Dgat2 ( Figures 11I, O ), Acaca ( Figures 11J, P ), and PPAR- ( Figures 11L, R ) were significantly decreased in the SHR+C75 group compared to the SHR+Vehicle group

A dual-crossing glioma targeting liposomal drug delivery system was then developed by conjugating peptide-22 and c(RGDfK), a ligand of integrin v 3 that showed ability to target glioma cells, to liposomes loaded with doxorubicin