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B12 absorption in the gut depends on a protein called intrinsic factor, which declines with age and can be compromised by certain medications and digestive conditions

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Vice versa, genetic risk factors affecting cellular metabolism might render particularly IECs sensitive to environmental triggers of inflammation, and thereby impair the regenerative capacity of the epithelium

85 In contrast to normal cells that mainly rely on oxidative phosphorylation in mitochondria to generate the energy required for the many cellular processes, cancer cells use aerobic glycolysis as a substitute to generate ATP, a phenomenon called the Warburg effect.86, 87, 88 Butyrate inhibits the growth of cancerous cells but has minimal effects on normal cells