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Additionally, it negatively regulates activator protein 1 (AP-1), mitogen-activated protein kinases (MAPK), and p53 pathways (Zhang et al., 2019)

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Exposed to MCNs/Ln/GD/FR NPs environments, the IC50 values for various anti-tumor drugs decrease obviously in PHLDA1 + tumor cells relative to PHLDA - ones, indicating enhanced anti-tumor efficacy (Supplementary Fig