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doi: 10.1056/NEJMoa2212948 9 Serrano-PozoADasSHymanBT

Libraries were prepared with the extracted DNA using a Kapa Biosystems kit as per manufacturers instruction (Massachusetts, USA), and hybridized on a custom designed 20MB panel (details of this panel are provided in the Suppl

Premature aging syndrome with osteosarcoma, cataracts, diabetes mellitus, osteoporosis, erythroid macrocytosis, severe growth and developmental deficiency