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To investigate the causal relationship between epigenetic clocks and common age-related eye diseases or glaucoma endophenotypes, Chen et al (354) conducted bidirectional two-sample Mendelian randomization and found that ARCs were linked to decreased HannumAge, a measure of extrinsic aging based on 71 age-related CpGs from whole blood samples of adults

We hypothesized that IgG would show the strongest association with histologic disease activity

The gap between the two is wider than most articles make it look, and knowing which side of that gap a product sits on is the difference between actual results and wasted money

At this stage, the before-and-after comparison becomes staggering