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Garnier S, Truong V, Brocheton J, Zeller T, Rovital M, Wild PS et al

An isolated view of this macromolecular complex shows the NuA4 HAT engaging the histone 4 (H4) tail, which penetrates one side of the NuA4 HAT cleft and is poised for acetylation, while the Polycomb complex-related protein Epl1 interacts on the opposite side, stabilising NuA4 binding to the nucleosome (Supplementary Fig