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However, some of the studies in the literature have low reliability due to limited sample size, lack of a control group, or being pilot studies

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One of the better characterized metabolic phenotypes present in tumor cells is the Warburg effect, which gives preference to ATP generation through glycolysis, even under normal oxygen concentrations, over ATP synthesis through the electron transport chain in the mitochondria (Warburg, 1956

For further investigation of carnitine potential in reversing MTX impact on energy status, the current work extended to assessing acetyl-CoA carboxylase (ACC1), which is an established controller of energy homeostasis [65]