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Inflammatory cytokines IL-1 and IL-18 present in the ovarian tissue and FF in PCOS patients alter the follicular microenvironment by binding to receptors like IL-1R and TLR4 on the GCs, activating NF-B, which subsequently translocates into the nucleus (50)

Plant-based expression systems have emerged in the past decade and already made an appearance during the 2014 Ebola epidemic when patients were treated with ZMapp, an antibody cocktail manufactured through molecular farming 83,84

However, it is important that the activation of Nrf2 caused by spices is usually transient and reversible, depending on the metabolism of those active ingredients, which is completely different from the continuous and dysregulated activation in cancer (135, 136)

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