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doi: 10.1016/j.cell.2018.10.001 76 PraharajMShenFLeeAJZhaoLNirschlTRTheodrosDet al

It is a tumor suppressor gene that plays a significant tumor-suppressive role in hepatocellular carcinoma and prostate ca 34,35

In the colonic cancer cell lines, unlike the ovarian cancer cells, inhibitory effect of glutamate was observed also in the sensitive cells, indicating the significant occurrence of system x c in HCT8 cells, although its activity is much lower than that of HCT8DDP cells