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Elevated levels of ROS increase the incidence of mtDNA mutations [41], and the accumulation of induced mtDNA mutations as well as restricted DNA repair capacity, together with errors during replication, lead to increased DNA damage and chromosome damage [42, 43]

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Mild fatigue or drowsiness reported in some subjects

concluded that the initial oral dose for patients without the variant should be 5 mg/kg every 12 h, which can be increased appropriately in the absence of peripheral neuropathy