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Evidence from a recent study demonstrates that DHA effectively attenuates profibrotic cytokine signaling in hepatic stellate cells (HSCs) by inhibiting TGF-1induced Smad2/3 phosphorylation and downregulating the expression of classical fibrogenic markers, including -SMA and collagen 1(I), in a dose-dependent fashion (Figure 1B) ( Numerous animal studies have consistently demonstrated DHAs potent capacity to suppress hepatic inflammation

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In addition to the involvement of type I and type II interferons (IFNs) in the innate immune system, crosstalk exists between IL21 (mainly secreted by Tfh cells) and B cell activating factor (BAFF) during B-cell activation ( Individual genetic susceptibility that is affected by multiple environmental factors can influence the development of pSS