glutathione peroxidase in the liver Frontiers A Literature Review of Glutathione

Studies have demonstrated that catalase overexpression diminishes smooth muscle growth and accelerates apoptosis, potentially via a mechanism involving COX-2 [110]

These antioxidant effects are thought to be mediated through a dual mechanism: indirectly, by improving systemic metabolism and cardiac energy efficiency (Usman et al., 2024), and more directly, through the inhibition of myocardial NOX2 expression and the activation of endogenous antioxidant pathways such as Nrf2(Preda et al., 2024)

[DOI] [PMC free article] [PubMed] [Google Scholar] 57.Pucci G., Minafra L., Bravat V., Calvaruso M., Turturici G., Cammarata F.P., Savoca G., Abbate B., Russo G., Cavalieri V., et al

doi: 10.1007/s12011-008-8219-3 72 PereiraT