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The authors showed that the inhibition of GSK-3 caused a reduction in PS-1 activity and subsequently inhibited the generation of A 40 and A 42 [245]

Autophagy flux in CA1 neurons of Alzheimer hippocampus: increased induction overburdens failing lysosomes to propel neuritic dystrophy

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The hepatocyte pyroptosis not only induce hepatocyte death directly, but also promote metabolic reprogramming and M1 polarization of macrophages through intercellular communication, which leads to the worsening of ALI