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In a Phase III study, 82.3% of patientswho had residual anemia after anti-C5 treatmentsaw a sustained increase in hemoglobin levels even without transfusions compared with 0% of those who stayed on anti-C5 treatments

Several factorsin addition to GSHhave been implicated in the cellular protection against oxidative stress, most of them being under the control of the master regulator NRF2 46

REDEFINE 2: Efficacy in Type 2 Diabetes REDEFINE 2, announced in March 2025, addressed a distinct population: 1,206 adults with obesity or overweight and type 2 diabetes across 12 countries, randomised in a 3:1 ratio to CagriSema or placebo for 68 weeks

Moore M, Wandera R, Xia Y-M, Du S-H, Butler J, Whanger P