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Moreover, insulin-like growth factor binding protein related proteins (IGFBPrPs) have been recently characterised, which aid the metabolic effects of the hormone but their role remains unclear [96, 97]

If your intake doesnt keep up with the rate at which your body uses B12, it creates a deficiency

Eight weeks is a long enough window to observe effects, and four weeks off is a real break that gives the methylation cycle time to normalize before the next block