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Where possible, SARS-CoV-2 vaccination should be administered while patients are taking the lowest dose of systemic corticosteroid[113]

Moreover, we found that Hcy induced neurodegeneration-like pathological changes in mitochondria in the brain via the inhibition of the NAD + /Sirt1 pathway, including defects in mitochondrial morphology, mitochondrial biogenesis, and mitophagy, ultimately leading to impairments in synapses and cognition, all of which were reversed by Ndufa1 upregulation

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Several transcription factors, including WRKY and NAC, have been identified as key regulators of ROS signaling and stress response pathways (Zhu, 2016