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The ascorbate-glutathione (AsA-GSH) cycle is critical for ROS detoxification, neutralizing H 2 O 2 using AsA as an electron donor, producing monodehydroascorbate (MDHAR) and dehydroascorbate (DHAR)

Gene Set Enrichment Analysis (GSEA) Affymetrix transcriptomic profiling data of E0771 and metM-Wnt lung tumors from DIO and nonobese (control) mice from previous studies conducted (GSE230471, GSE230470, GSE272326) [30, 31] were aggregated and expression levels generated via Transcriptome Analysis Console (Affymetrix, Santa Clara, CA) to correct for batch effects

However, diversity in trial designs, constrained sample numbers, and short follow-up durations limit the capacity to reach conclusive determinations