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CKD is always accompanied by intestinal inflammation and oxidative stress, which lead to rapid systemic translocation of bacterial-derived uraemic toxins, including indoxyl sulphate, phenyl sulphate and indole-3-acetic acid, and the consequent development and aggravation of renal fibrosis

The main cellular components of the tumor microenvironment include hepatoma cells, hepatocytes, hepatic stellate cells (HSCs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), immune cells (regulatory and cytotoxic T cells), endothelial cells, and various other cell types