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The decreased EpCAM caused the downregulation of CLDN1, CLDN7, OCLD and pIgR at the post-transcriptional level, and then the intestinal paracellular permeability increased and the dysbiosis of gut microbiota occurred, the paracellular flux of LPS from the intestinal lumen to blood also increased

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Rick Snyder has outlined a plan to address the long-term damage that children exposed to lead could face, including new screening measures to help identify potential behavioral problems, expanding a free breakfast program, offering professional support and case management when children under 6 are found to have high lead levels, and addung more child and adolescent health centers in the county