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This implies that upstream modulators like KEAP1 may be more important than direct Nrf2 modulation as the primary mechanism 104

Hexosamine biosynthetic pathway promotes protein glycosylation O -GlcNAcylation is one of the most common post-translational modifications in eukaryotic cells, via attachment of O -linked -D- N -acetylglucosamine ( O -GlcNAc) to Ser/Thr residue