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doi: 10.3389/frdem.2026.1745504 Received 13 November 2025 Revised 21 December 2025 Accepted 16 January 2026 Published 04 February 2026 Volume 5 - 2026 Edited by Matea Nikolac Perkovi, Rudjer Boskovic Institute, Croatia Reviewed by Xifeng Wang, First Affiliated Hospital of Nanchang University, China Paolo Abondio, IRCCS Institute of Neurological Sciences of Bologna (ISNB), Italy Updates Copyright 2026 Perezcano and Prez-Coria

Research has shown that apoptosis is intricately linked to the pathogenesis of certain diseases [136]

Its increase usually paralleled the inflammation severity 58,59

Our study has revealed that mutations and variants in exons 2 and 3 of AIFM1 are the risk factors to enhance the frequency of pathologic AIF3 splicing in brain of pediatric individuals with mitochondrial disorders