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The activation of NF-B in neurodegeneration occurs in response to oxidative stress, misfolded proteins, and infection

Among them, Bifidobacterium and Lactobacillus promote the secretion of SIgA, and in addition, Bifidobacterium and Lactobacillus mediate the balance of Treg/Th17 in relation to this, which affects cytokine homeostasis ( 3.2 Damage to the intestinal mucosal barrier induces and exacerbates multisystemic diseases There is growing evidence indicating that the intestinal mucosal barrier is impaired not only in digestive disorders but also in central nervous system (CNS) disorders, metabolic disorders, and in age-related diseases

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Gupta VB