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Therapeutic Implications: Restoring the Glutathione-Mitochondrial-Vascular Axis Understanding glutathione as a central integrator of redox, mitochondrial, and vascular signaling provides a clear rationale for interventions designed to restore homeostasis and cardiometabolic resilience

Hence, the validation of the physiological relevance of the detected interactions remains a major challenge

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However, in all 4 patient samples, S -cysteinylation was detected not only at Cys34 but also at other cysteine residues, Cys101 and Cys392, that form an intramolecular disulfide bond in native HSA