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In this work, we identify noncovalent TGR inhibitors with efficacy against schistosome infections in mice, meeting the criteria for lead progression indicated by WHO

The immunosuppressive effects of galectin-1 are mediated by several mechanisms, including polarization of macrophages towards an M2 anti-inflammatory phenotype, inhibition of the capacity of NK cells to kill cancer cells, and induction of regulatory T-cell infiltration [102, 105, 106]