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Caries are typically caused by acid-producing bacteria, such as Streptococcus and Lactobacillus , which ferment carbohydrates and create a low-pH environment within dental biofilms, leading to tooth demineralization 31,32

We order vitamin B12 and folate testing when a person with Down syndrome we are evaluating has symptoms described above, has a lab abnormality for which follow up testing of vitamin B12 and/or folate is indicated, or the person has a condition in which deficiency is common (e.g., celiac disease)

doi: 10.1073/pnas.0400337101

OFlaherty C, Rico de Souza A (2010) Hydrogen peroxide modifies human sperm peroxiredoxins in a dose-dependent manner