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Description

The proposed mechanism centers on activation of a beta-3 adrenergic-like pathway in adipocytes rather than via the canonical hGH receptor

P1NP (a formation marker), CTX (a resorption marker), vitamin D levels, calcium, and PTH all provide context about the current state of bone metabolism

The remaining authors declare no conflict of interest

In knock-in mice expressing DOR-eGFP, a challenge with SNC-80 but not ARM-390 induces a tolerance to analgesic response in a model of inflammatory pain with a concomitant G protein uncoupling in both brain and spinal cord homogenates (Pradhan et al., 2009)