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1 H NMR (600 MHz, D 2 O) : 7.66 (d, J = 8.0 Hz, 1H, H 12 ), 7.53 (d, J = 8.5 Hz, 1H, H 15 ), 7.29 (t, J = 7.5 Hz, 1H, H 14 ), 7.25 (s, 1H, H 11 ), 7.19 (t, J = 7.5 Hz, 1H, H 13 ), 5.57 (s, 1H, H 16 ), 3.99 (dd, J = 9.0, 5.0 Hz, 1 H, H 2 ), 3.39 (dd, J = 15.0, 5.0 Hz 1H, H 6 ), 3.22 (dd, J = 15.0, 5.0 Hz, 1H, H 6 )

Accordingly, monitoring of total concentrations may be misleading since free concentrations may be substantially elevated in patients with hepatic disease whereas total concentrations may appear to be normal [see BOXED WARNING , CONTRAINDICATIONS , and WARNINGS AND PRECAUTIONS ]

The pharmaceutical substance according to a therapeutic dose of metal-binding agents selected from the group of chemical substances having, DMPS, DTPA, EDTA, and penicillamine

GK: Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing original draft, Writing review & editing