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On the other hand, the Ka/Ks ratio of two duplicated gene pairs is equal to one, indicating that neutral selection occurred (Figure 5 and Supplementary Table 3), but only nine PavGST gene pairs have a ka/ks ratio greater than one, showing that positive selection was dominated

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It is important to note that most side effects are mild, transient, and resolve with continued use or dosage adjustment

Sixty showed a PDE5 inhibitory potency of 1.6 nM, and it significantly increased the levels of NO in human keratinocytes after 24 h from the treatment with a 10 M dose of 60 and up to 72 h [271]