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Growth hormone therapy can induce insulin resistance, elevate fasting glucose, worsen glycemic control in diabetics or pre-diabetics, increase risk of developing type 2 diabetes with long-term use, and require medication adjustments for individuals with existing diabetes

The resulting neuronal damage manifests as a spectrum of cognitive, psychiatric, and motor dysfunctions, with long-term consequences for brain structure and function

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"Induction of epithelial-mesenchymal transition (EMT)-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment"