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Insulin resistance is a major feature in T2DM development (Poznyak et al., 2020), glucose transporter defect, amyloid formation for -cell dysfunction (Rickels and Robertson, 2019)

Intravenous administration of 40 mol CrMP/kg BW to rats decreased mean arterial pressure, sinusoidal diameter, and hepatic blood flow, and induced hemolysis, marked inflammatory responses, and increased AST levels

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The absorbance was read at a wavelength of 450 nm using a microplate reader (Tecan, Switzerland)