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What made it even more effective is that it did not affect the activity of any other enzymes in the metabolic cycles which reduced the risks of any potential side-effects

R 2 , R 3 , R 4 , and R 5 are independently selected from the group consisting of: H, C 1-4 alkyl, halogen-substituted C 1-4 alkyl, NR 9 R 10 , and CN

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Not all medications and nutrients are small enough to get absorbed or need breakdown via gastric enzymes for activation for the sublingual route, but whenever possible there is a benefit to using this route as it bypasses potential damage/absorption issues in the GI tract