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Nanocarriers' development offers many advantages, including overcoming ocular barriers, promoting transcorneal permeability, prolonging drug residence time, reducing the dosing frequency, improving patient compliance, reducing drug degradation, achieving sustained/controlled release, drug targeting and gene delivery [23]

In addition, several GSTs are reported to participate in auxin transport and auxin binding as non-substrate ligands

By comprehensively correcting disorders across multiple metabolite axes through dietary interventions (such as supplementing specific prebiotics and fibers), probiotic/postbiotic therapies, or small-molecule inhibitors (such as targeting microbial enzymes CutC/D to inhibit TMAO generation), it is expected that more fundamental and effective management of liver diseases can be achieved