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Geroscience 42 , 409428 (2020)

Meaningful weight reduction is generally observed by weeks 12 to 16, with maximum weight loss tending to occur later in the treatment period, depending on the agent and dose

Post-procedure recovery applications include use after laser treatments, chemical peels, microneedling, and surgical procedures

Snapshot Proponents May help cleanse the bowels before medical procedures May relieve constipation Skeptics Most health claims are not backed by science The benefits from coffees active compounds are more effectively (and pleasantly) achieved by drinking it Used as part of fraudulent and expensive cancer therapies May cause digestive issues, bowel injuries, and electrolyte imbalances Use through History The first documented uses of coffee enemas for poisoning and post-operative care date back to the 19th century