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(2016) identified that Saikosaponin A could disrupt the formation of lipid rafts by depleting cholesterol and inhibiting TLR4 translocation into lipid rafts and thereby further activate the expression of LXR, ABCA1 and ABCG1

however, the genetic association of ApoE genotypes with late-onset sporadic Alzheimers disease (sAD) was only discovered 20 years later