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SKU: 60015265109
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In animal studies, BPTES and CB-839 did not show any apparent toxicity [41, 58]

Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma

Upon ligand binding, PPAR-alpha undergoes a conformational change and associates with the nuclear receptor of 9- cis retinoic acid (RXR), forming a heterodimer that binds to PPAR-alpha responsive elements in the promoter of multiple genes associated with fatty acid metabolism, such as CPT1 (beta-oxidation), DECR2 (unsaturated fatty acid synthesis), ACAA1 (peroxisomal fatty acid oxidation) and ACADVL (beta-oxidation of very-long chain fatty acids) [23]