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Lee-MacAry, A.E

Nuciferine modulates the gut microbiota and prevents obesity in high-fat diet-fed rats

Guo Lei, orcid.org/0009-0006-4877-5288 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

#ResearchPublication #Pharmacology #Hemorrhoids #PreclinicalResearch #Inflammation #Antioxidant #NutraceuticalResearch To view or add a comment, sign in STRUCTUREACTIVITY RELATIONSHIPS (SAR) Where chemistry defines clinical effect Small structural changes major pharmacologic outcomes Functional groups Hydrogen bonding & ionic interactions or potency Stereochemistry Enantiomers differ in efficacy, safety, and metabolism Lipophilicity (logP) Controls membrane penetration, tissue distribution, CNS access pKa & ionization Determines absorption, bioavailability, and receptor binding Ring systems & rigidity Influence receptor selectivity and intrinsic activity Metabolic hotspots Steric shielding reduces CYP metabolism half-life Key insight: Clinical response begins at the molecular level dose optimization starts with structure optimization