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Dual role of autophagy in stress-induced cell death in rheumatoid arthritis synovial fibroblasts

Alshaddi, et al

A 2002 study revealed that raising glutathione levels prolongs the patients pain-free walking distance, and improves local blood circulation

ATP7A dysfunction leads to abnormal mitochondrial redox status, which results in reduced mitochondrial glutathione and increased oxidative stress (Bhattacharjee, 2016)