what causes melanotic macule

what causes melanotic macule Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Melanotic macule. Benign. Dark spot

Name: what causes melanotic macule Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Melanotic macule. Benign. Dark spot
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Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Congenital Melanotic Macule of the Tongue: Report of Two Cases and Literature Review Head and Neck Pathology Springer Nature Link Oral Malignant Melanoma Oral Cancer Foundation Information and Resources about Oral Head and Neck Cancer A Black Spot on the Upper Gum for Many Years: Melanotic Macule Springer Nature Link

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Numerous researches have reported that silibinin can promote the apoptosis by regulating apoptotic-related proteins (e.g., Bax, Bcl-2, and Bcl-xL) and activating Caspases in lung, colon, renal, oral, pancreatic cancers, as well as endometrial carcinoma [920, 921]

Our results showed that LCLT supplementation was safe and well tolerated, and may be protective, since we found a decrease in coagulation disturbance markers, as well as reduction in the severity of lung alterations when given to patients with mild COVID-19 (Cohort 2)

Wallensten et al., 2023)

In addition, amino acids could be directly metabolized by some of these bacteria which own the ability to excrete numerous proteases and peptidases (Fan et al., 2000)