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Contribution of the N -acetyltransferase 2 polymorphism NAT2 * 6A to age-related hearing impairment

Its homeostasis is maintained by three major components: the endoplasmic reticulum (ER) as the primary intracellular reservoir, the plasma membrane as the regulator of extracellular influx, and mitochondria as a high-capacity and rapid-response buffer that sequesters cytosolic Ca 2+ surges through the mitochondrial calcium uniporter (MCU) to regulate metabolism, mitochondrial dynamics, and cell fate decisions

Consecutively, an oxidized form of protoporphyrin IX, heme , has been found in almost all large subunit size catalases [30]

It's advisable to discontinue use if these symptoms persist