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p53 Recent studies suggest that p53 plays an important role in controlling metabolism and ferroptosis and that p53 in normal cells can negatively regulate lipid synthesis and glycolysis and positively regulates oxidative phosphorylation and lipid catabolism

These data could also be used in future studies to improve the kinetics of our sensor by engineering the HT binding pocket, and more generally to design fluorogenic dyes or other robust, targeted sensors

The extract also lowered cfos and CGRP expression in the trigeminal nucleus caudalis, suggesting its antimigraine effect may involve dampening trigeminal activation and neuropeptide signaling

( F ) Representative images showing the colocalization of GFP-ATG2A-ER and Cherry-Sec61 in HeLa cells