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Simultaneously, silybin improves endothelial dysfunctiona critical link in the onset of inflammationby lowering asymmetric dimethylarginine (ADMA) levels, thereby reversing nitric oxide synthase inhibition and increasing the bioavailability of NO, which possesses anti-inflammatory and vasodilatory functions

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A significant reduction of steatosis was observed at ultrasound (from 72.7% of moderate-severe grade to 0% severe steatosis), accompanied by a statistically significant improvement of ballooning, portal and lobular inflammation and fibrosis