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NIR light irradiation produced heat that facilitated the release of OVA, resulting in increased concentrations of immune-related cytokines such as IL-6, IL-12, and TNF-, along with the activation of CD 8 T cells

Wang YJ, Guan Z, Xie LY, Zhao RX, Li YY, Guan ZP & Zhang FG

Therefore, these results indicate that B12 can stimulate T cell survival in patients with severe COVID-19

This reinforces the central role of the HFD in defining complex-specific incorporation and essential function, in line with observations in budding yeast (37)