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The expression levels of phosphorylated Janus kinase 2 (pJAK2) and phosphorylated signal transducer and activator of transcription 3 (pSTAT3) are elevated in liver tissue [117]

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In detail, these authors retrospectively evaluated the electronic health record database of PsO patients to assess the risk of incident inflammatory arthritis after initiation of biological therapies over a mean time span of 2.4 years, finding the risk of developing inflammatory arthritis to be significantly lower in patients under treatment with IL12/23 inhibitors (adjusted HR 0.58, 95% CI 0.430.76) or IL-23 inhibitors (0.41, 0.170.95) compared to patients treated with TNF inhibitors, while no significant difference was observed between IL-17 inhibitors (0.86, 0.541.38) and TNF inhibitors