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When we applied the method to the late-stage modification of an antifungal drug Triclosan, the desired para -aminated product ( 2u ) was isolated successfully in 83% yield

Expectations should be adjusted accordingly, with longer protocol durations (8 to 12 weeks), potentially higher doses, and understanding that improvement may reach 70 to 90 percent of normal rather than complete resolution

The mechanism behind these effects has been suggested to be the previously observed bacteriostatic properties of Pycnogenol (80)