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In contrast, thromboxane stimulates TXA 2 receptors to produce an increase in intracellular calcium, resulting in vasoconstriction in smooth muscle, and increased release of granules and aggregation in platelets

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Before aphaeresis, all donors of PBSC were treated subcutaneously once a day with G-CSF (Rhne-Poulenc Rorer, Lyon, France or Amgen-Roche Inc., Thousand Oaks, CA, USA), 10 g/kg/day for 4 to 6 days 63

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